Annotation Detail
Information
- Associated Genes
- PDCD4
- Associated Variants
-
PDCD4 EXPRESSION
PDCD4 EXPRESSION - Associated Disease
- lung cancer
- Source Database
- CIViC Evidence
- Description
- PDCD4 expression was associated with response to paclitaxel in a retrospective analysis of 77 patients after preclinical validation and mechanistic analysis of the biomarker.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/821
- Gene URL
- https://civic.genome.wustl.edu/links/genes/10573
- Variant URL
- https://civic.genome.wustl.edu/links/variants/337
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Lung Cancer
- Evidence Direction
- Supports
- Drug
- Paclitaxel
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25928036
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel | Sensitivity | true |