Annotation Detail
Information
- Associated Genes
- DNMT1
- Associated Variants
-
DNMT1 EXPRESSION
DNMT1 EXPRESSION - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- DNMT1 expression (mRNA expression from an independent study) correlated with sensitivity to decitabine (ρ, −0.443, Pearson regression analysis) in this preclinical study of 45 solid tumor cell lines. DNMT1 protein expression was also evaluated in two KRAS-mutant ovarian cancer cell lines pre and post-decitabine treatment showing downregulation following treatment.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/819
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1510
- Variant URL
- https://civic.genome.wustl.edu/links/variants/335
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Drug
- Decitabine
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25968887
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Decitabine | Sensitivity | true |