Annotation Detail
Information
- Associated Genes
- CBLC
- Associated Variants
-
CBLC EXPRESSION
CBLC EXPRESSION - Associated Disease
- cancer
- Source Database
- CIViC Evidence
- Description
- The E3 ubiquitin ligase, CBLC, was identified as a candidate biomarker for olaparib sensitivity in a siRNA screen and further validated in-vitro. In other words, expression of CBLC is predicted to confer resistance to olaparib.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/805
- Gene URL
- https://civic.genome.wustl.edu/links/genes/9705
- Variant URL
- https://civic.genome.wustl.edu/links/variants/326
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Cancer
- Evidence Direction
- Supports
- Drug
- Olaparib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 25883215
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Olaparib | Resitance or Non-Reponse | true |