Annotation Detail
Information
- Associated Genes
- FGFR1
- Associated Variants
-
FGFR1 EXPRESSION
FGFR1 EXPRESSION - Associated Disease
- gastric adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- FGFR inhibitor BGJ398 was most effective in a gastric cancer cell line model with high expression of FGFR1 and FGFR2IIIc.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/800
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1885
- Variant URL
- https://civic.genome.wustl.edu/links/variants/268
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Gastric Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Infigratinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26637881
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Infigratinib | Sensitivity | true |