Annotation Detail
Information
- Associated Genes
- AREG
- Associated Variants
-
AREG EXPRESSION
AREG EXPRESSION - Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- Five patients with acquired resistance to crizotinib showed high concentration of amphiregulin in malignant pleural effusions.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/781
- Gene URL
- https://civic.genome.wustl.edu/links/genes/389
- Variant URL
- https://civic.genome.wustl.edu/links/variants/315
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Crizotinib
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 23344087
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Crizotinib | Resitance or Non-Reponse | true |