Annotation Detail

Information

Associated Genes: NRG1
Associated Variants: NRG1 EXPRESSION
NRG1 EXPRESSION
Associated Disease: lung non-small cell carcinoma
Source Database: CIViC Evidence
Description: In-vivo studies of residual NSCLC tumors (xenografts of 5 cell lines) after chemotherapy found increased EGFR-family signaling and NRG1 expression. NRG1 inhibition (YW538.24.71 antibody) led to decreased tumor growth and enhanced magnitude and response to chemotherapy.
Variant Origin: N/A
Variant Origin: N/A
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/779
Gene URL: https://civic.genome.wustl.edu/links/genes/2593
Variant URL: https://civic.genome.wustl.edu/links/variants/314
Rating: 3
Evidence Type: Predictive
Disease: Lung Non-small Cell Carcinoma
Evidence Direction: Supports
Drug: Cisplatin,Gemcitabine,Carboplatin,Paclitaxel
Evidence Level: D
Clinical Significance: Sensitivity/Response
Pubmed: 23390248

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