Annotation Detail
Information
- Associated Genes
- NRG1
- Associated Variants
-
NRG1 EXPRESSION
NRG1 EXPRESSION - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- An NRG1-ERBB3 autocrine signal-transducing loop was identified in a subset of ovarian cancers and cell lines. Disruption of this loop led to decreased cell-growth in-vitro and prolonged survival in-vivo. An ERBB3 directed antibody (MM-121) inhibited tumor-growth in-vivo.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/778
- Gene URL
- https://civic.genome.wustl.edu/links/genes/2593
- Variant URL
- https://civic.genome.wustl.edu/links/variants/314
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Drug
- Seribantumab
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 20227043
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Seribantumab | Sensitivity | true |