Annotation Detail
Information
- Associated Genes
- ABL1
- Associated Variants
-
ABL1 BCR-ABL F311V
ABL1 BCR-ABL F311V - Associated Disease
- chronic myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- In a proliferation assay measuring tritiated thymidine incorporation in the presence of axitinib, Ba/F3 cells carrying the BCR-ABL1 variant showed similar sensitivity to axitinib in fusions with the L248R and F359I variants of ABL1 compared to those with wildtype ABL1 (IC50 of 1385nM vs. 823 nM), indicating resistance.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/7775
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4
- Variant URL
- https://civic.genome.wustl.edu/links/variants/2889
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Chronic Myeloid Leukemia
- Evidence Direction
- Supports
- Drug
- Axitinib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 25686603
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Axitinib | Resitance or Non-Reponse | true |