Annotation Detail
Information
- Associated Genes
- NRG1
- Associated Variants
-
NRG1 EXPRESSION
NRG1 EXPRESSION - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- NRG1 upregulation or ERBB2 amplification were the main causes of resistance to cetuximab in-vivo and in-vitro in this study. Inhibition of ERBB2/ERBB3 signaling restored cetuximab sensitivity.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/777
- Gene URL
- https://civic.genome.wustl.edu/links/genes/2593
- Variant URL
- https://civic.genome.wustl.edu/links/variants/314
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- Cetuximab
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 21900593
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cetuximab | Resitance or Non-Reponse | true |