Annotation Detail
Information
- Associated Genes
- ABL1
- Associated Variants
-
ABL1 BCR-ABL F311V
ABL1 BCR-ABL F311V - Associated Disease
- chronic myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- In a proliferation assay measuring tritiated thymidine incorporation in the presence of axitinib, Ba/F3 cells carrying the BCR-ABL1 variant showed reduced incorporation when treated with axitinib in fusions with the T315V variant of ABL1 compared to fusions with wildtype ABL1 (IC50 of 45nM vs. 823 nM), indicating the T315V variant induces sensitivity compared to BCR-ABL1 without secondary variants.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/7766
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4
- Variant URL
- https://civic.genome.wustl.edu/links/variants/2885
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Chronic Myeloid Leukemia
- Evidence Direction
- Supports
- Drug
- Axitinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25686603
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Axitinib | Sensitivity | true |