Annotation Detail

Information
Associated Genes
BRAF
Associated Variants
BRAF p.Asp634Gly (p.D634G) ( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
BRAF p.Asp634Gly (p.D634G) ( ENST00000646891.2, ENST00000496384.7, ENST00000644969.2, ENST00000288602.11 )
Associated Disease
cancer
Source Database
CIViC Evidence
Description
In a BRAF-mutation inducible model in the NIH3T3 cell line, class 3 BRAF mutations (G466V, G466E, D594G, D594N, and G596R) were resistant to vemurafenib but sensitive to MEK-inhibitor trametinib.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/7760
Gene URL
https://civic.genome.wustl.edu/links/genes/5
Variant URL
https://civic.genome.wustl.edu/links/variants/611
Rating
2
Evidence Type
Predictive
Disease
Cancer
Evidence Direction
Supports
Drug
Trametinib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
28783719
Drugs
Drug NameSensitivitySupported
TrametinibSensitivitytrue