Annotation Detail
Information
- Associated Genes
- NRG1
- Associated Variants
-
NRG1 EXPRESSION
NRG1 EXPRESSION - Associated Disease
- head and neck squamous cell carcinoma
- Source Database
- CIViC Evidence
- Description
- In non-HER2 amplified cell lines, sensitivity to HER2 kinase inhibitor lapatinib was found mainly in cell-lines with elevated NRG1 expression and HER3 activation. This aberration was mainly identified in head and neck cancer cell lines.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/776
- Gene URL
- https://civic.genome.wustl.edu/links/genes/2593
- Variant URL
- https://civic.genome.wustl.edu/links/variants/314
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Head And Neck Squamous Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Lapatinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 21840482
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Lapatinib | Sensitivity | true |