Annotation Detail
Information
- Associated Genes
- ERBB4
- Associated Variants
-
ERBB4 MUTATION
ERBB4 MUTATION - Associated Disease
- melanoma
- Source Database
- CIViC Evidence
- Description
- ERBB4 was the most commonly mutated protein tyrosine kinase in this study in melanoma (19% in 79 patients). Seven of the identified mutations in ERBB4 (E317K, E452K, E542K, R544W, E563K, E836K and E872K) were transforming and activating in-vitro. ERBB4 inhibition with shRNA or lapatinib led to reduced cell growth.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/770
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1734
- Variant URL
- https://civic.genome.wustl.edu/links/variants/310
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Melanoma
- Evidence Direction
- Supports
- Drug
- Lapatinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 19718025
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Lapatinib | Sensitivity | true |