Annotation Detail
Information
- Associated Genes
- RET
- Associated Variants
-
RET p.Met918Thr (p.M918T)
(
ENST00000340058.6,
ENST00000713926.1,
ENST00000355710.8,
ENST00000615310.5 )
RET p.Met918Thr (p.M918T) ( ENST00000340058.6, ENST00000355710.8, ENST00000615310.5, ENST00000713926.1 ) - Associated Disease
- thyroid gland medullary carcinoma
- Source Database
- CIViC Evidence
- Description
- The use of AZD1480 on RET-mutated/rearranged cell lines in vitro led to strong repression of tyroid cancer cell growth.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/77
- Gene URL
- https://civic.genome.wustl.edu/links/genes/42
- Variant URL
- https://civic.genome.wustl.edu/links/variants/113
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Thyroid Gland Medullary Carcinoma
- Evidence Direction
- Supports
- Drug
- JAK2 Inhibitor AZD1480
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23056499
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| JAK2 Inhibitor AZD1480 | Sensitivity | true |