Annotation Detail
Information
- Associated Genes
- ALK
- Associated Variants
- ALK EML4-ALK G1269A
- Associated Disease
- lung non-small cell carcinoma
- Source Database
- CIViC Evidence
- Description
- 11 patients with crizotinib-resistant NSCLC were analyzed for this study. Two harbored the G1269A mutation that also led to crizotinib-resistance in-vitro.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/764
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1
- Variant URL
- https://civic.genome.wustl.edu/links/variants/308
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Lung Non-small Cell Carcinoma
- Evidence Direction
- Supports
- Drug
- Crizotinib
- Evidence Level
- C
- Clinical Significance
- Resistance
- Pubmed
- 22235099
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Crizotinib | Resitance or Non-Reponse | true |