Annotation Detail

Information
Associated Genes
PIK3CA
Associated Variants
PIK3CA AMPLIFICATION ( ENST00000263967.4 )
PIK3CA AMPLIFICATION ( ENST00000263967.4, ENST00000497599.5 )
Associated Disease
ovary epithelial cancer
Source Database
CIViC Evidence
Description
One platinum-refractory epithelial ovarian cancer patient with PTEN loss and PIK3CA amplification had a partial response on treatment with PI3K inhibitor pictilisib (GDC-0941) in this phase 1 study. A total of 60 patients with advanced solid tumors were enrolled in this study.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/756
Gene URL
https://civic.genome.wustl.edu/links/genes/37
Variant URL
https://civic.genome.wustl.edu/links/variants/212
Rating
2
Evidence Type
Predictive
Disease
Epithelial Ovarian Cancer
Evidence Direction
Supports
Drug
Pictilisib
Evidence Level
C
Clinical Significance
Sensitivity/Response
Pubmed
25370471
Drugs
Drug NameSensitivitySupported
PictilisibSensitivitytrue