Annotation Detail
Information
- Associated Genes
- SYK
- Associated Variants
-
SYK OVEREXPRESSION
(
ENST00000375754.9 )
SYK OVEREXPRESSION ( ENST00000375754.9 ) - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- Overexpression and high p-SYK/SYK ratio were associated with resistance to paclitaxel. Inhibition of SYK with R406 resensitized cell lines to paclitaxel.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/752
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5572
- Variant URL
- https://civic.genome.wustl.edu/links/variants/305
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Drug
- Paclitaxel
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 26096845
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel | Resitance or Non-Reponse | true |