Annotation Detail
Information
- Associated Genes
- RET
- Associated Variants
-
RET p.Cys634Trp (p.C634W)
(
ENST00000713926.1,
ENST00000340058.6,
ENST00000615310.5,
ENST00000355710.8 )
RET p.Cys634Trp (p.C634W) ( ENST00000340058.6, ENST00000355710.8, ENST00000615310.5, ENST00000713926.1 ) - Associated Disease
- thyroid gland medullary carcinoma
- Source Database
- CIViC Evidence
- Description
- Medullary thyroid cancer cells with RET C634W mutation are insensitive to motesanib, compared to wild-type RET.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/75
- Gene URL
- https://civic.genome.wustl.edu/links/genes/42
- Variant URL
- https://civic.genome.wustl.edu/links/variants/112
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Thyroid Gland Medullary Carcinoma
- Evidence Direction
- Supports
- Drug
- Motesanib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 21422803
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Motesanib | Resitance or Non-Reponse | true |