Annotation Detail
Information
- Associated Genes
- ALK
- Associated Variants
- ALK CAD-ALK
- Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- A patient with colorectal cancer harboring CAD-ALK fusion gene was treated with ALK inhibitor entrectinib resulted in durable objective tumor response.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/7481
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1
- Variant URL
- https://civic.genome.wustl.edu/links/variants/2769
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- Entrectinib
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26633560
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Entrectinib | Sensitivity | true |