Annotation Detail
Information
- Associated Genes
- RIT1
- Associated Variants
-
RIT1 MUTATION
RIT1 MUTATION - Associated Disease
- lung adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- RIT1 mutations were identified in approx. 2% of lung adenocarcinomas (5/87 in the "oncogene negative" samples of TCGA - no RIT1 mutations were observed in 143 samples with a known driver mutation). GDC-0941 impaired tumor growth of NCI-H2110 (RIT1 M90I mutated) xenografts in nude mice. GDC-0941 and AZD-6244 (selumetinib) impaired colony formation in-vitro. Combined PI3K/MEK inhibition was more effective than single agent treatment in-vitro.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/742
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4875
- Variant URL
- https://civic.genome.wustl.edu/links/variants/297
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Lung Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Pictilisib,Selumetinib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24469055
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Pictilisib | Sensitivity | true |
| Selumetinib | Sensitivity | true |