Annotation Detail
Information
- Associated Genes
- RET
- Associated Variants
-
RET EXPRESSION
RET EXPRESSION - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- Vandetanib was tested in 4 murine models of patient-derived xenografts. In xenografts with high expression of EGFR or RET, vandetanib led to tumor regression, in those without high expression, vandetanib slowed tumor growth.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/740
- Gene URL
- https://civic.genome.wustl.edu/links/genes/42
- Variant URL
- https://civic.genome.wustl.edu/links/variants/295
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Vandetanib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26686064
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Vandetanib | Sensitivity | true |