Annotation Detail
Information
- Associated Genes
- MYD88
- Associated Variants
-
MYD88 OVEREXPRESSION
(
ENST00000417037.8 )
MYD88 OVEREXPRESSION ( ENST00000417037.8 ) - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- In this retrospective analysis of 211 breast cancer tissues, MYD88 overexpression was correlated with poor survival. In-vitro experiments showed a decrease in sensitivity towards paclitaxel in cell-lines with high MYD88 expression.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/734
- Gene URL
- https://civic.genome.wustl.edu/links/genes/3742
- Variant URL
- https://civic.genome.wustl.edu/links/variants/292
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Paclitaxel
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 26596839
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel | Resitance or Non-Reponse | true |