Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
-
BRAF V600E+V600M
BRAF V600E+V600M - Associated Disease
- melanoma
- Source Database
- CIViC Evidence
- Description
- A single patient with BRAF V600E/V600M bi-allelic mutation responded to the V600E drug dabrafenib.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/73
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5
- Variant URL
- https://civic.genome.wustl.edu/links/variants/13
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Melanoma
- Evidence Direction
- Supports
- Drug
- Dabrafenib
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23031422
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dabrafenib | Sensitivity | true |