Annotation Detail
Information
- Associated Genes
- ERBB3
- Associated Variants
-
ERBB3 OVEREXPRESSION
(
ENST00000267101.8 )
ERBB3 OVEREXPRESSION ( ENST00000267101.8 ) - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- High expression of ERBB3 (her3) was associated with shorter overall survival (OS) from Cetuximab treatment in patients with metastatic colorectal cancer. Gene expression measures (qRT-PCR) were available for 103 patients.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/729
- Gene URL
- https://civic.genome.wustl.edu/links/genes/1733
- Variant URL
- https://civic.genome.wustl.edu/links/variants/289
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- Cetuximab
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 25520391
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cetuximab | Resitance or Non-Reponse | true |