Annotation Detail

Information
Associated Genes
FGFR1
Associated Variants
FGFR1 AMPLIFICATION ( ENST00000425967.8 )
FGFR1 AMPLIFICATION ( ENST00000425967.8 )
Associated Disease
breast cancer
Source Database
CIViC Evidence
Description
Case report in a HR positive, Her2/neu negative breast cancer patient harboring an FGFR1 amplification. The patient responded to treatment to Pazopanib - including a near CR of brain metastases. Duration of Treatment or median PFS was not reported at the time of publication.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/7246
Gene URL
https://civic.genome.wustl.edu/links/genes/1885
Variant URL
https://civic.genome.wustl.edu/links/variants/267
Rating
2
Evidence Type
Predictive
Disease
Breast Cancer
Evidence Direction
Supports
Drug
Pazopanib
Evidence Level
C
Clinical Significance
Sensitivity/Response
Pubmed
29223982
Drugs
Drug NameSensitivitySupported
PazopanibSensitivitytrue