Annotation Detail
Information
- Associated Genes
- FBXW7
- Associated Variants
-
FBXW7 MUTATION
FBXW7 MUTATION - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- 65 patients were retrospectively analyzed for mutational profiles predictive of response to EGFR-inhibitors (cetuximab or panitumumab). FBXW7 mutation was found to be more prevalent in non-responders (5 mutations) than responders (1 mutation).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/718
- Gene URL
- https://civic.genome.wustl.edu/links/genes/12903
- Variant URL
- https://civic.genome.wustl.edu/links/variants/281
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- Panitumumab,Cetuximab
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 26508446
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cetuximab | Resitance or Non-Reponse | true |
| Panitumumab | Resitance or Non-Reponse | true |