Annotation Detail

Information

Associated Genes: PTEN
Associated Variants: PTEN DELETION ( ENST00000371953.8 )
PTEN DELETION ( ENST00000371953.8 )
Associated Disease: cancer
Source Database: CIViC Evidence
Description: All three patients with PTEN loss had benefit from adding Buparlisib to carboplatin+paclitaxel therapy in a phase I study in advanced solid cancers.
Variant Origin: somatic
Variant Origin: Somatic
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/714
Gene URL: https://civic.genome.wustl.edu/links/genes/41
Variant URL: https://civic.genome.wustl.edu/links/variants/214
Rating: 3
Evidence Type: Predictive
Disease: Cancer
Evidence Direction: Supports
Drug: Paclitaxel,Carboplatin,Buparlisib
Evidence Level: B
Clinical Significance: Sensitivity/Response
Pubmed: 25672916

Drugs