Annotation Detail
Information
- Associated Genes
- MTOR
- Associated Variants
-
MTOR p.His1968Tyr (p.H1968Y)
(
ENST00000361445.9,
ENST00000703140.1 )
MTOR p.His1968Tyr (p.H1968Y) ( ENST00000361445.9, ENST00000703140.1 ) - Associated Disease
- melanoma
- Source Database
- CIViC Evidence
- Description
- In a cell line (HEK293T) with expression of H1968Y or P2213S mTOR mutations, LY294002 and AZD5363 were more effective than temsirolimus or BYL719 in suppressing cell growth.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/713
- Gene URL
- https://civic.genome.wustl.edu/links/genes/2073
- Variant URL
- https://civic.genome.wustl.edu/links/variants/283
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Melanoma
- Evidence Direction
- Supports
- Drug
- Capivasertib,PI3K/BET Inhibitor LY294002
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26490311
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Capivasertib | Sensitivity | true |
| PI3K/BET Inhibitor LY294002 | Sensitivity | true |