Annotation Detail
Information
- Associated Genes
- PIK3CA
- Associated Variants
-
PIK3CA p.Glu545Lys (p.E545K)
(
ENST00000263967.4,
ENST00000643187.1 )
PIK3CA p.Glu545Lys (p.E545K) ( ENST00000263967.4, ENST00000643187.1 ) - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- PIK3CA E545K mutation increased sensitivity to AKT inhibitor MK-2206 and PI3K inhibitor GDC-0941 in a breast cancer cell line model.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/710
- Gene URL
- https://civic.genome.wustl.edu/links/genes/37
- Variant URL
- https://civic.genome.wustl.edu/links/variants/104
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Pictilisib,Akt Inhibitor MK2206
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23888070
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Akt Inhibitor MK2206 | Sensitivity | true |
| Pictilisib | Sensitivity | true |