Annotation Detail

Information
Associated Genes
AKT2
Associated Variants
AKT2 EXPRESSION
AKT2 EXPRESSION
Associated Disease
breast cancer
Source Database
CIViC Evidence
Description
In HER2+ metastatic breast cancer treated with trastuzumab (n = 74 patients), the expression of AKT2 and pAkt-Thr308 and/or pAkt-Ser473 localized in nucleus+cytoplasm was associated with an improved time to progression (TTP) and overall survival (OS) compared to AKT2 negative tumors as measured by immunohistochemistry.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/706
Gene URL
https://civic.genome.wustl.edu/links/genes/254
Variant URL
https://civic.genome.wustl.edu/links/variants/278
Rating
3
Evidence Type
Predictive
Disease
Breast Cancer
Evidence Direction
Supports
Drug
Trastuzumab
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
22842582
Drugs
Drug NameSensitivitySupported
TrastuzumabSensitivitytrue