Annotation Detail
Information
- Associated Genes
- PARP1
- Associated Variants
-
PARP1 OVEREXPRESSION
PARP1 OVEREXPRESSION - Associated Disease
- malignant peripheral nerve sheath tumor
- Source Database
- CIViC Evidence
- Description
- The majority of MPNST samples were positive for PARP staining. Overall, moderate to high expression of PARP1 and PARP2 was observed (Table 1)....Overall, treatment continued for 60 d at which point 5 out of 7 mice in the AZD2281 treatment group were alive versus 0 out of 7 mice in the control group (Fig. 4). These results indicated that treatment with AZD2281 significantly increased the survival of mice with metastatic disease.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/7016
- Gene URL
- https://civic.genome.wustl.edu/links/genes/199
- Variant URL
- https://civic.genome.wustl.edu/links/variants/2586
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Malignant Peripheral Nerve Sheath Tumor
- Evidence Direction
- Supports
- Drug
- Olaparib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26650448
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Olaparib | Sensitivity | true |