Annotation Detail

Information
Associated Genes
JAK2
Associated Variants
JAK2 p.Val617Phe (p.V617F) ( ENST00000381652.4 )
JAK2 p.Val617Phe (p.V617F) ( ENST00000381652.4 )
Associated Disease
bone marrow cancer
Source Database
CIViC Evidence
Description
The SNP rs10974944 in the Jak2 locus is associated with increased predisposition for JAK2 V617F mutation and its associated cancer.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/7
Gene URL
https://civic.genome.wustl.edu/links/genes/28
Variant URL
https://civic.genome.wustl.edu/links/variants/64
Rating
4
Evidence Type
Diagnostic
Disease
Bone Marrow Cancer
Evidence Direction
Supports
Evidence Level
B
Clinical Significance
Positive
Pubmed
19287384
Drugs