Annotation Detail
Information
- Associated Genes
- RET
- Associated Variants
- RET KIF5B-RET
- Associated Disease
- lung adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- A case study of a patient with EGFR, KRAS, BRAF, HER2, ALK, ROS1 and MET negative adenocarcinoma of the lung. FISH analysis revealed a KIF5B-RET fusion. The RET inhibitor Vandetanib led to remission in the patient.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/698
- Gene URL
- https://civic.genome.wustl.edu/links/genes/42
- Variant URL
- https://civic.genome.wustl.edu/links/variants/273
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Lung Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Vandetanib
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23584301
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Vandetanib | Sensitivity | true |