Annotation Detail
Information
- Associated Genes
- ABCG2
- Associated Variants
-
ABCG2 p.Gln141Lys (p.Q141K)
(
ENST00000237612.8,
ENST00000515655.5,
ENST00000650821.1 )
ABCG2 p.Gln141Lys (p.Q141K) ( ENST00000237612.8, ENST00000515655.5, ENST00000650821.1 ) - Associated Disease
- ovarian cancer
- Source Database
- CIViC Evidence
- Description
- The ABCG2 Q141K variant was correlated with higher progression-free survival and overall survival in 511 ovarian cancer patients treated with platinum + taxane-based chemotherapy.
- Variant Origin
- Common Germline
- Variant Origin
- Common Germline
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/671
- Gene URL
- https://civic.genome.wustl.edu/links/genes/7451
- Variant URL
- https://civic.genome.wustl.edu/links/variants/260
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Ovarian Cancer
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Better Outcome
- Pubmed
- 22112610
Drugs