Annotation Detail

Information
Associated Genes
GSTP1
Associated Variants
GSTP1 c.[313A>G;341=] ( ENST00000398606.10 )
GSTP1 c.[313A>G;341=] ( ENST00000398606.10 )
Associated Disease
colorectal cancer
Source Database
CIViC Evidence
Description
Patients with the GSTP1 I105V variant had greater response to FOLFOX-4 treatment, longer progression-free survival, and longer overall survival. 166 Chinese patients with metastatic colorectal carcinoma who had been treated with FOLFOX-4 were used in this study.
Variant Origin
Common Germline
Variant Origin
Common Germline
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/670
Gene URL
https://civic.genome.wustl.edu/links/genes/2473
Variant URL
https://civic.genome.wustl.edu/links/variants/259
Rating
4
Evidence Type
Predictive
Disease
Colorectal Cancer
Evidence Direction
Supports
Drug
FOLFOX Regimen
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
19922504
Drugs
Drug NameSensitivitySupported
FOLFOX RegimenSensitivitytrue