Annotation Detail
Information
- Associated Genes
- NTRK1
- Associated Variants
- NTRK1 NTRK1 FUSIONS NTRK1 NTRK1 FUSIONS
- Associated Disease
- cancer
- Source Database
- CIViC Evidence
- Description
- In a Phase 1/2 study involving 15 pediatric patients with infantile fibrosarcoma or soft tissue sarcoma, 8 patients had NTRK1 fusions. The patients were administered Larotrectinib, and 7 out of 8 patients showed objective response, with 2 complete and 5 partial responses. The patient without objective response had soft tissue sarcoma, and showed stable disease.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/6569
- Gene URL
- https://civic.genome.wustl.edu/links/genes/3983
- Variant URL
- https://civic.genome.wustl.edu/links/variants/419
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Cancer
- Evidence Direction
- Supports
- Drug
- Larotrectinib
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 29606586
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Larotrectinib | Sensitivity | true |