Annotation Detail
Information
- Associated Genes
- PTEN
- Associated Variants
-
PTEN DELETION
(
ENST00000371953.8 )
PTEN DELETION ( ENST00000371953.8 ) - Associated Disease
- bladder carcinoma
- Source Database
- CIViC Evidence
- Description
- PTEN loss is associated with reduced response to mTOR inhibitors in patients with bladder cancer.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/644
- Gene URL
- https://civic.genome.wustl.edu/links/genes/41
- Variant URL
- https://civic.genome.wustl.edu/links/variants/214
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Bladder Carcinoma
- Evidence Direction
- Supports
- Drug
- Everolimus
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 23989949
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Everolimus | Resitance or Non-Reponse | true |