Annotation Detail
Information
- Associated Genes
- TP53
- Associated Variants
-
TP53 DNA BINDING DOMAIN MUTATION
TP53 DNA BINDING DOMAIN MUTATION - Associated Disease
- oral squamous cell carcinoma
- Source Database
- CIViC Evidence
- Description
- Oral squamous cell carcinoma patients with TP53 mutations in the DNA binding domain (L2, L3 and the LSH motif) have significantly reduced cumulative survival when compared to patients with TP53 mutations outside of this DNA binding domain. These mutations were also significantly associated with locoregional failure, cervical lymph node metastasis and distant metastasis, likely contributing to this finding.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/641
- Gene URL
- https://civic.genome.wustl.edu/links/genes/45
- Variant URL
- https://civic.genome.wustl.edu/links/variants/242
- Rating
- 4
- Evidence Type
- Prognostic
- Disease
- Oral Squamous Cell Carcinoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 12509970
Drugs