Annotation Detail
Information
- Associated Genes
- ABL1
- Associated Variants
- ABL1 p.Phe336Leu (p.F336L) ABL1 p.Phe336Leu (p.F336L)
- Associated Disease
- chronic myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- Ponatinib has shown to be effective in patients with BCR-ABL kinase domain mutations like F317L.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/639
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4
- Variant URL
- https://civic.genome.wustl.edu/links/variants/241
- Rating
- 5
- Evidence Type
- Predictive
- Disease
- Chronic Myeloid Leukemia
- Evidence Direction
- Supports
- Drug
- Ponatinib
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25349473
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Ponatinib | Sensitivity | true |