Annotation Detail

Information
Associated Genes
CDK12
Associated Variants
CDK12 LOSS-OF-FUNCTION
CDK12 LOSS-OF-FUNCTION
Associated Disease
ovarian serous carcinoma
Source Database
CIViC Evidence
Description
In models of high-grade serous ovarian cancer (HGS-OVCa), CDK12 attenuation was sufficient to confer sensitivity to PARP1/2 inhibition, suppression of DNA repair via homologous recombination, and reduced expression of BRCA1.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/623
Gene URL
https://civic.genome.wustl.edu/links/genes/12112
Variant URL
https://civic.genome.wustl.edu/links/variants/236
Rating
4
Evidence Type
Predictive
Disease
Ovarian Serous Carcinoma
Evidence Direction
Supports
Drug
Olaparib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
24240700
Drugs
Drug NameSensitivitySupported
OlaparibSensitivitytrue