Annotation Detail

Information

Associated Genes: ERBB2
Associated Variants: ERBB2 OVEREXPRESSION
ERBB2 OVEREXPRESSION
Associated Disease: salivary gland cancer
Source Database: CIViC Evidence
Description: Case report of a a 58 year old man with multiple bone metastases after local therapy of a carcinoma ex pleomorphic adenoma one year earlier. The original tumor tested strongly positive for HER2/neu by immunohistochemistry. The patient was treated with trastuzumab, capecitabine, and zoledronic acid. He experienced total resolution of symptoms and repeat FDG-PET scan after three cycles revealed interval disease resolution. Continued treatment resulted in maintenance of disease control for over 2 years.
Variant Origin: N/A
Variant Origin: N/A
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/6171
Gene URL: https://civic.genome.wustl.edu/links/genes/20
Variant URL: https://civic.genome.wustl.edu/links/variants/875
Rating: 3
Evidence Type: Predictive
Disease: Salivary Gland Cancer
Evidence Direction: Supports
Drug: Trastuzumab,Zoledronic Acid,Capecitabine
Evidence Level: C
Clinical Significance: Sensitivity/Response
Pubmed: 20504363

Drugs