Annotation Detail
Information
- Associated Genes
- ERBB2
- Associated Variants
-
ERBB2 OVEREXPRESSION
ERBB2 OVEREXPRESSION - Associated Disease
- salivary gland cancer
- Source Database
- CIViC Evidence
- Description
- Case report of a 61-year-old caucasian male with a renal mass and subsequent liver metastases. Histopathological examination of the liver led to the diagnosis of metastastic adenocarcinoma of the salivary Gland, which had been diagnosed and treated in the Patient 20 years earlier. IHC revealed Her2/neu, 3+. The patient was treated successfully with trastuzumab/paclitaxel with near-complete response as measured by PET-CT scans for more than a year.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/6170
- Gene URL
- https://civic.genome.wustl.edu/links/genes/20
- Variant URL
- https://civic.genome.wustl.edu/links/variants/875
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Salivary Gland Cancer
- Evidence Direction
- Supports
- Drug
- Paclitaxel,Trastuzumab
- Evidence Level
- C
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23826550
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Paclitaxel | Sensitivity | true |
| Trastuzumab | Sensitivity | true |