Annotation Detail

Information

Associated Genes: PTEN
Associated Variants: PTEN DELETION ( ENST00000371953.8 )
PTEN DELETION ( ENST00000371953.8 )
Associated Disease: Solid Tumor
Source Database: CIViC Evidence
Description: No objective responses were observed in the PTEN deficient cohort. Four out of 6 patients with stable disease (SD) had SD or better for ≥6 cycles, 2 of which had PTEN deficient tumors. Conclusion The addition of buparlisib to high dose carboplatin and paclitaxel was not tolerable. The combination did not reveal significant clinical activity amongst a small and heterogenous group of PTEN deficient tumors.
Variant Origin: somatic
Variant Origin: Somatic
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/5957
Gene URL: https://civic.genome.wustl.edu/links/genes/41
Variant URL: https://civic.genome.wustl.edu/links/variants/214
Rating: 4
Evidence Type: Predictive
Disease: Solid Tumor
Evidence Direction: Does Not Support
Drug: Carboplatin,Buparlisib,Paclitaxel
Evidence Level: B
Clinical Significance: Sensitivity/Response
Pubmed: 28281183

Drugs