Annotation Detail

Information
Associated Genes
EGFR
Associated Variants
EGFR COPY NUMBER VARIATION ( ENST00000275493.7 )
EGFR COPY NUMBER VARIATION ( ENST00000275493.7 )
Associated Disease
lung non-small cell carcinoma
Source Database
CIViC Evidence
Description
Among TKI-treated patients, increased EGFR gene copy number appears to be associated with improved survival outcomes.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/5925
Gene URL
https://civic.genome.wustl.edu/links/genes/19
Variant URL
https://civic.genome.wustl.edu/links/variants/191
Rating
4
Evidence Type
Predictive
Disease
Lung Non-small Cell Carcinoma
Evidence Direction
Supports
Drug
Gefitinib,Erlotinib
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
27664271
Drugs
Drug NameSensitivitySupported
ErlotinibSensitivitytrue
GefitinibSensitivitytrue