Annotation Detail

Information

Associated Genes: RRM1
Associated Variants: RRM1 UNDEREXPRESSION ( ENST00000300738.10 )
RRM1 UNDEREXPRESSION ( ENST00000300738.10 )
Associated Disease: lung non-small cell carcinoma
Source Database: CIViC Evidence
Description: The study began with a total of 443 patients that were randomly assigned to either regimen A (Paclitaxel and cisplatin with gemcitabine) or regimen B ( cisplatin and vinorelbine). Of those patients, 261 had tissue available for RRM1 evaluation. In regimen B, survival increased significantly in patients with low RRM1 expression as compared to those with a high expression (P=0.046). However, in regimen A, the increase in survival for patients with low RRM1 expression as opposed to those with a high RRM1 expression was not as significant (P=0.366).
Variant Origin: Unknown
Variant Origin: Unknown
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/5599
Gene URL: https://civic.genome.wustl.edu/links/genes/5051
Variant URL: https://civic.genome.wustl.edu/links/variants/1257
Rating: 3
Evidence Type: Predictive
Disease: Lung Non-small Cell Carcinoma
Evidence Direction: Supports
Drug: Gemcitabine,Paclitaxel,Vinorelbine
Evidence Level: B
Clinical Significance: Sensitivity/Response
Pubmed: 23038758

Drugs