Annotation Detail

Information
Associated Genes
RRM1
Associated Variants
RRM1 UNDEREXPRESSION ( ENST00000300738.10 )
RRM1 UNDEREXPRESSION ( ENST00000300738.10 )
Associated Disease
pancreatic cancer
Source Database
CIViC Evidence
Description
There were 68 patients enrolled in this study, 28 of which were treated with gemcitabine. Of those 28, 14 patients had a low RRM1 expression and 14 had a high RRM1 expression. Only the patients with low RRM1 expression received a significant benefit from gemcitabine (p=0.0010) whereas the benefit for those with a high RRM1 expression was not significantly better (p=0.3309). The study also tested the role of ERCC1 expression and its correlation to RRM1 expression. It was found that patients with a combined high RRM1 and ERCC1 expression had good prognosis with the highest survival rate (P=0.0127).
Variant Origin
N/A
Variant Origin
N/A
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/5506
Gene URL
https://civic.genome.wustl.edu/links/genes/5051
Variant URL
https://civic.genome.wustl.edu/links/variants/1257
Rating
3
Evidence Type
Predictive
Disease
Pancreatic Cancer
Evidence Direction
Supports
Drug
Gemcitabine
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
19543324
Drugs
Drug NameSensitivitySupported
GemcitabineSensitivitytrue