Annotation Detail
Information
- Associated Genes
- FLT3
- Associated Variants
-
FLT3 MUTATION
FLT3 MUTATION - Associated Disease
- acute myeloid leukemia
- Source Database
- CIViC Evidence
- Description
- Midostaurin is FDA-approved for the treatment of newly-diagnosed acute myeloid leukemia patients harboring FLT3 mutations.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/5261
- Gene URL
- https://civic.genome.wustl.edu/links/genes/24
- Variant URL
- https://civic.genome.wustl.edu/links/variants/519
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Acute Myeloid Leukemia
- Evidence Direction
- Supports
- Drug
- Midostaurin
- Evidence Level
- A
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 28546144
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Midostaurin | Sensitivity | true |