Annotation Detail
Information
- Associated Genes
- ATM
- Associated Variants
-
ATM UNDEREXPRESSION
(
ENST00000278616.10 )
ATM UNDEREXPRESSION ( ENST00000278616.10 ) - Associated Disease
- stomach cancer
- Source Database
- CIViC Evidence
- Description
- A randomized phase 2 trial investigating the efficiency of Olaparib plus Paclitaxel vs. Placebo plus Paclitaxel in recurrent or metastatic gastric cancer patients. 123 patients received treatment. Combination treatment did not significantly improve ORR (26,4% vs 19,1%) or PFS (3,91m vs 3,55 m) but OS (13,8 m vs. 8,3 m) in the overall cohort. A subcohort of ATM low expressing tumours (14%) experienced a greater improvement of OS (not reached vs. 8,2 m) and a trend towards improved PFS (5,29 m vs 3,68 m).
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/5215
- Gene URL
- https://civic.genome.wustl.edu/links/genes/69
- Variant URL
- https://civic.genome.wustl.edu/links/variants/179
- Rating
- 1
- Evidence Type
- Predictive
- Disease
- Stomach Cancer
- Evidence Direction
- Supports
- Drug
- Olaparib,Paclitaxel
- Evidence Level
- B
- Pubmed
- 26282658
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Olaparib | N/A | true |
| Paclitaxel | N/A | true |