Annotation Detail
Information
- Associated Genes
- SMAD4
- Associated Variants
-
SMAD4 MUTATION
SMAD4 MUTATION - Associated Disease
- pancreatic adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- In a study of 89 patients with adenocarcinoma of the pancreas who underwent a pancreaticoduodenectomy, those with mutations in SMAD4 had shorter overall survival than wild-type patients.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/511
- Gene URL
- https://civic.genome.wustl.edu/links/genes/77
- Variant URL
- https://civic.genome.wustl.edu/links/variants/216
- Rating
- 3
- Evidence Type
- Prognostic
- Disease
- Pancreatic Adenocarcinoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Poor Outcome
- Pubmed
- 19584151
Drugs