Annotation Detail

Information
Associated Genes
PTEN
Associated Variants
PTEN DELETION ( ENST00000371953.8 )
PTEN DELETION ( ENST00000371953.8 )
Associated Disease
prostate cancer
Source Database
CIViC Evidence
Description
In prostate cancer xenographs, PTEN null tumors had a significant decrease in cell size and proliferation when treated with Temsirolimus (CCI-779).
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/507
Gene URL
https://civic.genome.wustl.edu/links/genes/41
Variant URL
https://civic.genome.wustl.edu/links/variants/214
Rating
4
Evidence Type
Predictive
Disease
Prostate Cancer
Evidence Direction
Supports
Drug
Temsirolimus
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
11504908
Drugs
Drug NameSensitivitySupported
TemsirolimusSensitivitytrue